research-two

Research

We investigate the molecular logic of mechanoceptive and synaptic pathways.

One part of the lab investigates molecular actors that belong to the class of adhesion-type G protein-coupled receptors. These molecules form a large group of surface receptors that constitute natural chimeras between an extracellular adhesion moiety and a transmembrane metabotropic signalling unit. We have discovered that specific adhesion GPCRs partake in developmental processes such as planar cell polarity, and have contributed to the understanding how adhesion and signalling is functionally combined within these mysterious surface receptors.

Recent results from our experiments have defined adhesion GPCRs as mechanoreceptors suggesting a novel scientific framework to study and understand their physiological profiles in a multitude of tissues and cell types including neurons, glia, muscle, vasculature and the heart.

Another emphasis of our work is on the elucidation of molecular rules that govern the scaffolding and functionalisation of synaptic contacts, and specifically the presynaptic active zone. These highly ordered organelles constitute the site where neuronal excitation is coupled to synaptic secretion. The molecular lattice coordinating these phenomena is of breathtaking complexity whilst neurosecretion is executed at high temporal and spatial precision. We seek to shed light how these properties arise.

To study these phenomena we use the fruitfly Drosophila melanogaster and the the roundworm Caenorhabditis elegans employing their vast genetic, molecular biological, imaging and functional toolkits.

the-team

Team

Tobias Langenhan
Principal Investigator
Phone: +49 931 31-88681
Orchid IDCV
Nicole Scholz
Postdoctoral Fellow
Phone: +49 931 31-83341
Maria Oppmann
Technician
Phone: +49 931 31-81334
Chonglin Guan
Ph.D. student (jointly with Kittel Lab)
Phone: +49 931 31-81804
Matthias Nieberler
M.D. student
Phone: +49 931 31-83922
Achmed Mrestani
M.D. student (jointly with Heckmann Lab)
Phone: +49 931 31-83341
Steffen Altrichter
Ph.D. student
Uta Strobel
Lab Assistant
our-awesome-work

Publications

2016

Adhesion G protein-coupled receptors in nervous system development and disease
Langenhan T#, Piao X#, Monk KR#
Nature Reviews Neuroscience (Epub ahead of print)
DOI

Effects of transgenic expression of botulinum toxins in Drosophila
Backhaus P, Langenhan T, Neuser K
Journal of Neurogenetics 30:22-31
DOI


2016

August 14th, 2016admin

2016

August 14th, 2016admin

2015

The Adhesion GPCR Latrophilin/CIRL shapes mechanosensation
Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ#, Langenhan T#
Cell Reports 11:866-874.
DOI | PDF

Model organisms in GPCR research
Langenhan T#, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR#
Molecular Pharmacology 88:596-603.
DOI

Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms
Monk K, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I
Molecular Pharmacology 88:617-623.
DOI

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
Hamann J,#, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB,#
Pharmacological Reviews 67(2):338-367.
DOI


2015

May 14th, 2016admin

2015

May 14th, 2016admin

2014

Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications
Dawydow A, Gueta R, Ljaschenko D, Ullrich S, Hermann M, Ehmann N, Gao S, Fiala A, Langenhan T, Nagel G#, Kittel RJ#
Proceedings of the National Academy of Sciences of the USA 111(38):13972-7.
DOI

New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors
Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X
Annals of the New York Academy of Sciences 1333(1):43-64.
DOI


2014

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2014

May 14th, 2016admin

2013

Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins
Prömel S, Langenhan T,#, Araç D,#
Trends in Pharmacological Sciences 34 (8):470-478
DOI

Sticky signaling – Adhesion class G protein-coupled receptors take the stage
Langenhan T,#, Aust G, Hamann J
Science Signaling 6 (276):re3
DOI | PDF (Access through www.adhesiongpcr.org)

Adhäsions-G-Protein-gekoppelte Rezeptoren — rätselhafte Riesen
Prömel S, Aust G, Langenhan T, Schöneberg T
Biospektrum 19 (7):717-719
DOI


2013

May 14th, 2016admin

2013

May 14th, 2016admin

2012

Dissecting signaling and functions of adhesion G protein-coupled receptors
Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T
Annals of the New York Academy of Sciences 1276 (1):1-25
DOI

The GPS motif is a molecular switch for bimodal activities of Adhesion-class G protein-coupled receptors
Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP*, Langenhan T*,#
Cell Reports 2 (2):321-331
DOI | PDF

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCRs in mouse
Prömel S#, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Grosse J, Schöneberg T, Russ AP, Langenhan T#
Developmental Dynamics 241 (10):1591-1602
DOI


2012

May 14th, 2016admin

2012

May 14th, 2016admin

2010

The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse
Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Davies B, Aparicio SAJR, Grosse J, Russ AP
PLoS One 5 (11):e14047
DOI | PDF

Latrophilin signalling in tissue polarity and morphogenesis
Langenhan T, Russ AP
Advances in Experimental Medicine and Biology 706:37-48 (Adhesion-GPCRs: Structure to Function, edited by Simon Yona and Martin Stacey)
DOI

Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency
McGuinness L, Taylor C, Taylor RDT, Yau C, Langenhan T, Hart ML, Christian H, Tynan PW, Donnelly P, Emptage NJ
Neuron 68 (6):1109–1127
DOI


2010

May 14th, 2016admin

2010

May 14th, 2016admin

2009

Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo
Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP
Developmental Cell 17 (4):494-504
DOI


2009

May 14th, 2016admin

2009

May 14th, 2016admin

2008

Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain
Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID
Structure 16 (6):944-953
DOI


2008

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2008

May 14th, 2016admin

2006

Ciliary neurotrophic factor (CNTF) in the olfactory system of rats and mice
Langenhan T
Annals of Anatomy 188 (5):411–413
DOI


2006

May 14th, 2016admin

2006

May 14th, 2016admin

2005

Ciliary neurotrophic factor-immunoreactivity in olfactory sensory neurons
Langenhan T, Sendtner M, Holtmann B, Carroll P, Asan E
Neuroscience 134 (4):1179–1194
DOI


2005

May 14th, 2016admin

2005

May 14th, 2016admin

2003

Ciliary neurotrophic factor in the olfactory bulb of rats and mic
Asan E, Langenhan T, Holtmann B, Bock H, Sendtner M, Carroll P
Neuroscience 120 (1):99–112
DOI


2003

May 14th, 2016admin

2003

May 14th, 2016admin

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